Kinetoplastid glucose transporters

On the Evolution of Hexose Transporters in Kinetoplastid Potozoans

Glucose, an almost universally used energy and carbon source, is processed through several well-known metabolic pathways, primarily glycolysis. Glucose uptake is considered to be the first step in glycolysis. In kinetoplastids, a protozoan group that includes relevant human pathogens, the importance of glucose uptake in different phases of the life cycles is well established, and hexose transpo...

Glucose transporters in obesity

L’obCsitC, pathologie frtquente dans les sociCtCs industrialiskes, est caractQiste par un sur-diveloppement du tissu adipeux. Nous avons CtudiC un moditle animal d’obksitk, le rat Zucker gCnCtiquement obkse. D b l’iige de 30 jours, les cellules adipeuses des rats mutants transportent beaucoup plus de glucose que celles des temoins normaux des memes portCes. Cette anomalie repose sur une augment...

Glucose transporters in preimplantation development.

The inability of the embryo to utilize glucose as a fuel before compaction has been an area of much speculation. It is suggested that limitations in glucose transporter processes are the prime reasons for this. The recent identification of GLUT3 as the transporter responsible for the uptake of maternal glucose after compaction may provide the missing link in this puzzle. Furthermore, the coinci...

Targeting of mammalian glucose transporters.

Glucose transporters in mammalian brain.

(;lucose is the primary energy source for mammalian brain and a continuous supply is vital for normal cerebral function. At rest, the brain is responsible for metabolizing up to 60% of the available circulating glucose, and the efficient transport of glucose across the blood-brain barrier (BRH) and into the various cells that make up the brain is essential. Of the six facilitative glucose trans...